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Effect of GDNF on neuroblast proliferation and photoreceptor survival: additive protection with docosahexaenoic acid
(Association for Research in Vision and Ophthalmology, 2001-11)
Purpose. In a previous study, it was reported that docosahexaenoic acid (DHA) is essential to postpone apoptosis and to promote differentiation of rat retina photoreceptors in vitro. In the current study, the protective ...
Glucocorticoid and progesterone mechanisms in photoreceptor survival
(Academic Press Ltd - Elsevier Science Ltd, 2020-01)
Death of retinal photoreceptors is the basis of prevalent blinding diseases. Since steroids might have a therapeutic role in retinal degenerations, we compared the protective effects of dexamethasone and progesterone on ...
Docosahexaenoic acid prevents apoptosis of retina photoreceptors by activating the ERK/MAPK pathway
(Wiley Blackwell Publishing, Inc, 2006-07-26)
Identifying the trophic factors for retina photoreceptors and the intracellular pathways activated to promote cell survival is crucial for treating retina neurodegenerative diseases. Docosahexaenoic acid (DHA), the major ...
Sphingosine-1-Phosphate Is a Key Regulator of Proliferation and Differentiation in Retina Photoreceptors
(Association for Research in Vision and Ophthalmology, 2009-09)
PURPOSE. Identifying the cues required for survival and development of photoreceptors is essential for treating retina neurodegenerations. We previously established that glial derived neurotrophic factor (GDNF) stimulates ...
Light, lipids and photoreceptor survival: live or let die?
(Royal Society of Chemistry, 2015-09)
Due to its constant exposure to light and its high oxygen consumption the retina is highly sensitive to oxidative damage, which is a common factor in inducing the death of photoreceptors after light damage or in retina ...
Pigment epithelium-derived factor (PEDF) and derived peptides promote survival and differentiation of photoreceptors and induce neurite-outgrowth in amacrine neurons
(Wiley Blackwell Publishing, Inc, 2021-12-16)
Pigment epithelium-derived factor (PEDF) is a cytoprotective protein for the retina. We hypothesize that this protein acts on neuronal survival and differentiation of photoreceptor cells in culture. The purpose of the ...
Ceramide-1-phosphate: a new mediator of survival and development in retina photoreceptors
(Association For Research In Vision And Ophthalmology, 2011-08)
Purpose. Simple sphingolipids control crucial cellular processes in several cell types. We demonstrated that sphingolipids such as ceramide, sphingosine and sphingosine-1-phosphate are key mediators in the regulation of ...
Retinoid X Receptors Activation is Essential for Docosahexanoic Acid Protection of Retina Photoreceptors
(American Society For Biochemistry And Molecular Biology, 2013-05)
We have established that docosahexaenoic acid (DHA), the major polyunsaturated fatty acid in the retina, promotes survival of rat retina photoreceptors during early development in vitro and upon oxidative stress by activating ...